What nonparametric test can be used to determine whether a significant change in periodontal status has occurred over time?Q1)Using Question 9.2 in the textbook, what nonparametric test can be used to determine whether a significant change in periodontal status has occurred over time? Explain in your own words what the answer means.Q2)Using Question 9.3 in the textbook, implement the procedure in Question 9.2 and report a p-value. Explain in your own words what the answer meansQ3) Using Question 9.11 in the textbook, what nonparametric test can be used to determine whether a significant change in periodontal status has occurred over time? Explain in your own words what the answer meansQ4) Using Question 10.22 in the textbook, is the distribution of stage at disease significantly different between Caucasians and African American women with breast cancer who are younger than 50 years of age? What were the null and alternative hypotheses? Explain in your own words what the answer meansQ5) Using Question 10.24 in the textbook, is there any relationship btween the types of treatment and the response? What are the null and alternative hypotheses? Explain in your own words what the answer meansQ6) Using Question 10.52 in the textbook, what is the reproducibility of adverse events and negligence designations (be sure to answer both)? Which seems to be more reproducible – adverse events or negligence designations? Explain in your own words what your answer means.Q7) Using Question 13.9 in the textbook, is the association between OC use and bacteriuria, after controlling for age, significant? Explain in your own words what your answer means.Q8) Using Question 13.10 in the textbook, estimate OR in favor of bacteriuria for OC users vs. non-OC users after controlling for age. Explain in your own words what your answer means.Q9) Using Question 13.85 in the textbook, among those with no pre-existing fractures, does raloxifene affect the incidencen of new fractures? Explain in your own words what you answer means.Q10) Using Question 13.85 in the textbook, what are the relative risks and the associated 95% CI of relative risk of new fractures among those randomized to ralxifene vs. placebo? Explain in your own words what your answers mean