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COH 320 Week# 3 Discussion 1

Cancer is considered by many a primarily genetic disease. However, what role does a lifestyle choice, such as smoking or a high cholesterol diet, play in the development of cancer?

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Although genetics plays a major role in the development of cancer, lifestyle choices such as smoking, obesity, and high cholesterol diet also plays a part in getting cancer. An example is breast cancer. Among the avoidable risk factors for breast cancer during the life of a woman, obesity and overweight are important contributors to the development of breast cancer. According to study done by Khan, Afaq, & Mukhtar (2010) on patients diagnosed with invasive breast cancer and receiving neoadjuvant chemotherapy before surgery, obese patients were more likely to have hormone-negative tumors, stage III tumors, and worse overall survival at a median follow-up time of 4.1 years. In patients treated on prospective clinical trials, obese patients had a higher incidence of inflammatory breast cancer, compared with normal or underweight patients. Having more fat tissues can increase a person’s chance of getting breast cancer by raising the estrogen levels. Women who are also overweight tends to have a higher level of insulin, which has been linked to some cancers, including breast cancer. Diet has also been shown to play a role in the development of cancer. According to Khan, Afaq, & Mukhtar (2010), an association

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